PTEN knockdown alters dendritic spine/protrusion morphology, not density

PTEN knockdown alters dendritic spine/protrusion morphology, not density

Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are implicated in neuropsychiatric disorders including autism. Previous studies report that PTEN knockdown in neurons in vivo leads to increased spine density and synaptic activity. To better characterize synaptic changes in...

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Main Authors: Haws, Michael E. (Author), Jaramillo, Thomas C. (Author), Espinosa, Felipe (Author), J. Widman, Allie (Author), Stuber, Garret D. (Author), Sparta, Dennis R. (Author), Russo, Scott J. (Author), Parada, Luis F. (Author), Stavarache, Mihaela (Author), Kaplitt, Michael (Author), Bonci, Antonello (Author), Powell, Craig M. (Author), Tye, Kay (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2016-05-24T23:54:56Z.
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