A single-molecule characterization of p53 search on DNA
The tumor suppressor p53 slides along DNA while searching for its cognate site. Central to this process is the basic C-terminal domain, whose regulatory role and its coordination with the core DNA-binding domain is highly debated. Here we use single-molecule techniques to characterize the search pro...
Main Authors: | Tafvizi, Anahita (Contributor), Huang, Fang (Author), Fersht, Alan R. (Author), Mirny, Leonid A. (Contributor), van Oijen, Antoine M. (Author) |
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Other Authors: | Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor) |
Format: | Article |
Language: | English |
Published: |
National Academy of Sciences (U.S.),
2016-06-02T20:55:13Z.
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Subjects: | |
Online Access: | Get fulltext |
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