Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors

Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors

The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian...

Full description

Bibliographic Details
Main Authors: Chowanadisai, Winyoo (Author), Messerli, Shanta M. (Author), Miller, Daniel Handel (Contributor), Medina, Jamie E. (Author), Hamilton, Joshua W. (Author), Messerli, Mark A. (Author), Brodsky, Alexander S. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2016-07-05T17:25:09Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items