Cisplatin Resistant Spheroids Model Clinically Relevant Survival Mechanisms in Ovarian Tumors
The majority of ovarian tumors eventually recur in a drug resistant form. Using cisplatin sensitive and resistant cell lines assembled into 3D spheroids we profiled gene expression and identified candidate mechanisms and biological pathways associated with cisplatin resistance. OVCAR-8 human ovarian...
Main Authors: | Chowanadisai, Winyoo (Author), Messerli, Shanta M. (Author), Miller, Daniel Handel (Contributor), Medina, Jamie E. (Author), Hamilton, Joshua W. (Author), Messerli, Mark A. (Author), Brodsky, Alexander S. (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor) |
Format: | Article |
Language: | English |
Published: |
Public Library of Science,
2016-07-05T17:25:09Z.
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Subjects: | |
Online Access: | Get fulltext |
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