Optogenetic activation of intracellular adenosine A[subscript 2A] receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Optogenetic activation of intracellular adenosine A[subscript 2A] receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and impair memory

Human and animal studies have converged to suggest that caffeine consumption prevents memory deficits in aging and Alzheimer's disease through the antagonism of adenosine A2A receptors (A2ARs). To test if A2AR activation in the hippocampus is actually sufficient to impair memory function and to...

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Main Authors: Li, P. (Author), Rial, D. (Author), Canas, P. M. (Author), Yoo, J.-H (Author), Li, W. (Author), Zhou, X. (Author), Wang, Y. (Author), van Westen, G. J. P. (Author), Payen, M.-P (Author), Augusto, E. (Author), Gonçalves, N. (Author), Tomé, A. R. (Author), Li, Z. (Author), Wu, Z. (Author), Hou, X. (Author), Zhou, Y. (Author), PIJzerman, Ad (Author), Boyden, Edward Stuart (Contributor), Cunha, R. A. (Author), Qu, J. (Author), Chen, J.-F (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Media Laboratory (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2016-07-13T16:56:34Z.
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