A Computational Model of Inhibition of HIV-1 by Interferon-Alpha

A Computational Model of Inhibition of HIV-1 by Interferon-Alpha

Type 1 interferons such as interferon-alpha (IFNα) inhibit replication of Human immunodeficiency virus (HIV-1) by upregulating the expression of genes that interfere with specific steps in the viral life cycle. This pathway thus represents a potential target for immune-based therapies that can alter...

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Bibliographic Details
Main Authors: Browne, Edward P. (Contributor), Letham, Benjamin (Contributor), Rudin, Cynthia (Contributor)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor), Massachusetts Institute of Technology. Operations Research Center (Contributor), Sloan School of Management (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2016-07-14T14:28:54Z.
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