Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

The recent discovery that normal and neoplastic epithelial cells re-enter the stem cell state raised the intriguing possibility that the aggressiveness of carcinomas derives not from their existing content of cancer stem cells (CSCs) but from their proclivity to generate new CSCs from non-CSC popula...

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Main Authors: Chaffer, Christine L (Author), Marjanovic, Nemanja D (Author), Lee, Tony (Author), Bell, George (Author), Kleer, Celina G (Author), Reinhardt, Ferenc (Author), D'Alessio, Ana C (Author), Young, Richard A (Author), Weinberg, Robert A (Author), Young, Richard A. (Contributor), Weinberg, Robert A (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Weinberg, Robert A. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-08-10T19:04:55Z.
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