Single-Cell Analysis Reveals that Expression of Nanog Is Biallelic and Equally Variable as that of Other Pluripotency Factors in Mouse ESCs

Single-Cell Analysis Reveals that Expression of Nanog Is Biallelic and Equally Variable as that of Other Pluripotency Factors in Mouse ESCs

The homeodomain transcription factor Nanog is a central part of the core pluripotency transcriptional network and plays a critical role in embryonic stem cell (ESC) self-renewal. Several reports have suggested that Nanog expression is allelically regulated and that transient downregulation of Nanog...

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Main Authors: Wang, Haoyi (Author), Cheng, Albert Wu (Contributor), Katz, Yarden (Contributor), Buganim, Yosef (Author), Jaenisch, Rudolf (Contributor), Faddah, Dina A. (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Whitehead Institute for Biomedical Research (Contributor), Faddah, Dina Adel (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-08-11T18:15:31Z.
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