Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

Distinct Prion Strains Are Defined by Amyloid Core Structure and Chaperone Binding Site Dynamics

Yeast prions are self-templating protein-based mechanisms of inheritance whose conformational changes lead to the acquisition of diverse new phenotypes. The best studied of these is the prion domain (NM) of Sup35, which forms an amyloid that can adopt several distinct conformations (strains) that pr...

Full description

Bibliographic Details
Main Authors: Frederick, Kendra K (Author), Debelouchina, Galia Tzvetanova (Contributor), Kayatekin, Can (Author), Dorminy, Tea (Contributor), Jacavone, Angela (Contributor), Griffin, Robert Guy (Contributor), Lindquist, Susan (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor), Francis Bitter Magnet Laboratory (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-08-26T14:02:07Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items