Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production

Artemisinin is a potent antimalarial drug; however, it suffers from unstable and insufficient supply from plant source. Here, we established a novel multivariate-modular approach based on experimental design for systematic pathway optimization that succeeded in improving the production of amorphadie...

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Bibliographic Details
Main Authors: Zhang, Congqiang (Author), Zou, Ruiyang (Author), Chen, Xixian (Author), Stephanopoulos, Gregory (Contributor), Too, Heng-Phon (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor)
Format: Article
Language:English
Published: Springer Berlin Heidelberg, 2016-09-21T19:01:43Z.
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