Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

Loss of Tet Enzymes Compromises Proper Differentiation of Embryonic Stem Cells

Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and are dynamically expressed during development. Whereas loss of individual Tet enzymes or combined deficiency of Tet1/2 allows for embryogenesis, the effect of complete loss of Tet activity and 5hmC marks in de...

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Main Authors: Dawlaty, Meelad M (Author), Breiling, Achim (Author), Le, Thuc (Author), Barrasa, M. Inmaculada (Author), Raddatz, Günter (Author), Gao, Qing (Author), Powell, Benjamin E (Author), Cheng, Albert W (Author), Faull, Kym F (Author), Lyko, Frank (Author), Jaenisch, Rudolf (Contributor)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-10-13T20:08:07Z.
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