Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

β1-Integrins are essential for angiogenesis. The mechanisms regulating integrin function in endothelial cells (EC) and their contribution to angiogenesis remain elusive. Brag2 is a guanine nucleotide exchange factor for the small Arf-GTPases Arf5 and Arf6. The role of Brag2 in EC and angiogenesis an...

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Main Authors: Manavski, Yosif (Author), Carmona, Guillaume (Contributor), Bennewitz, Katrin (Author), Tang, Zhongshu (Author), Zhang, Fan (Author), Sakurai, Atsuko (Author), Zeiher, Andreas M. (Author), Gutkind, J. Silvio (Author), Li, Xuri (Author), Kroll, Jens (Author), Dimmeler, Stefanie (Author), Chavakis, Emmanouil (Author)
Other Authors: Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer-Verlag, 2016-10-19T20:21:11Z.
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