Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes

The mechanisms underlying the development of complications in type 1 diabetes (T1D) are poorly understood. Disease modeling of induced pluripotent stem cells (iPSCs) from patients with longstanding T1D(disease duration ≥ 50 years) with severe (Medalist +C) or absent to mild complications (Medalist −...

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Main Authors: Bhatt, Shweta (Author), Gupta, Manoj K (Author), Khamaisi, Mogher (Author), Martinez, Rachael (Author), Gritsenko, Marina A (Author), Wagner, Bridget K (Author), Guye, Patrick (Contributor), Busskamp, Volker (Author), Shirakawa, Jun (Author), Wu, Gongxiong (Author), Liew, Chong Wee (Author), Clauss, Therese R (Author), Valdez, Ivan (Author), El Ouaamari, Abdelfattah (Author), Dirice, Ercument (Author), Takatani, Tomozumi (Author), Keenan, Hillary A (Author), Smith, Richard D (Author), Church, George (Author), Weiss, Ron (Contributor), Wagers, Amy J (Author), Qian, Wei-Jun (Author), King, George L (Author), Kulkarni, Rohit N (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-11-17T18:01:26Z.
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