Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses

Infiltration of regulatory T (Treg) cells into many tumor types correlates with poor patient prognoses. However, mechanisms of intratumoral Treg cell function remain to be elucidated. We investigated Treg cell function in a genetically-engineered mouse lung adenocarcinoma model and found Treg cells...

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Bibliographic Details
Main Authors: Bronson, Roderick T (Author), Joshi, Nikhil (Contributor), Akama-Garren, Elliot H. (Contributor), Lu, Yisi (Contributor), Lee, Da-Yae (Contributor), Chang, Gregory (Contributor), Li, Amy (Contributor), DuPage, Michel J. (Contributor), Tammela, Tuomas (Contributor), Kerper, Natanya R. (Contributor), Farago, Anna F. (Contributor), Robbins, Rebecca (Contributor), Crowley, Denise G. (Contributor), Jacks, Tyler E. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier/Cell Press, 2016-11-17T19:22:39Z.
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