The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

The emergence of drug resistance is a major limitation of current antimalarials. The discovery of new druggable targets and pathways including those that are critical for multiple life cycle stages of the malaria parasite is a major goal for developing next-generation antimalarial drugs. Using an in...

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Main Authors: Pepper, L. R. (Author), Cortese, J. F. (Author), Estiu, G. (Author), Galinsky, K. (Author), Zuzarte-Luis, V. (Author), Derbyshire, E. R. (Author), Ribacke, U. (Author), Lukens, A. K. (Author), Santos, S. A. (Author), Patel, V. (Author), Clish, C. B. (Author), Sullivan, W. J. (Author), Zhou, H. (Author), Bopp, S. E. (Author), Schimmel, P. (Author), Clardy, J. (Author), Mota, M. M. (Author), Keller, T. L. (Author), Whitman, M. (Author), Wiest, O. (Author), Wirth, D. F. (Author), Mazitschek, R. (Author), Lindquist, Susan (Contributor), Herman, Jonathan D. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Herman, Jonathan D (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-12-05T19:17:05Z.
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