Inactivation of the retinoblastoma gene yields a mouse model of malignant colorectal cancer
The retinoblastoma gene (Rb) is mutated at significant frequency in various human epithelial tumors, including colorectal cancer, and is strongly associated with metastatic disease. However, sole inactivation of Rb in the mouse has so far failed to yield epithelial cancers. Here, we specifically ina...
Main Authors: | Bronson, R T (Author), Parisi, Tiziana (Contributor), Lees, Jacqueline (Contributor) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group,
2016-12-05T21:07:23Z.
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Subjects: | |
Online Access: | Get fulltext |
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