Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

The microbial adaptive immune system CRISPR mediates defense against foreign genetic elements through two classes of RNA-guided nuclease effectors. Class 1 effectors utilize multiprotein complexes, whereas Class 2 effectors rely on single-component effector proteins such as the well-characterized Ca...

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Bibliographic Details
Main Authors: Makarova, Kira S (Author), van der Oost, John (Author), Koonin, Eugene V (Author), Zetsche, Bernd (Contributor), Gootenberg, Jonathan S (Contributor), Abudayyeh, Omar Osama (Contributor), Slaymaker, Ian (Contributor), Essletzbichler, Patrick (Contributor), Volz, Sara E. (Contributor), Joung, Julia (Contributor), Regev, Aviv (Contributor), Zhang, Feng (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-07T21:38:01Z.
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