Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

Single-Cell Genomics Unveils Critical Regulators of Th17 Cell Pathogenicity

Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity...

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Bibliographic Details
Main Authors: Gaublomme, Jellert T (Author), Yosef, Nir (Author), Lee, Youjin (Author), Gertner, Rona S (Author), Yang, Li V (Author), Wu, Chuan (Author), Pandolfi, Pier Paolo (Author), Mak, Tak (Author), Satija, Rahul (Author), Kuchroo, Vijay K (Author), Park, Hongkun (Author), Regev, Aviv (Contributor), Shalek, Alexander K (Contributor)
Other Authors: Institute for Medical Engineering and Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-09T16:25:38Z.
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