C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against foreign genetic elements via DNA or RNA-DNA interference. We characterize the class 2 type VI CRISPR-Cas effector C2c2 and demonstrate its RNA-guided ri...

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Main Authors: Shmakov, S. (Author), Makarova, K. S. (Author), Semenova, E. (Author), Minakhin, L. (Author), Severinov, K. (Author), Koonin, E. V. (Author), Regev, Aviv (Contributor), Gootenberg, Jonathan S (Contributor), Konermann, Silvana M (Contributor), Joung, Julia (Contributor), Slaymaker, Ian (Contributor), Cox, David Benjamin Turitz (Contributor), Lander, Eric Steven (Contributor), Zhang, Feng (Contributor), Abudayyeh, Omar O. (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Abudayyeh, Omar Osama (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-12-09T20:58:39Z.
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