Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

Phosphorylation of ETS1 by Src Family Kinases Prevents Its Recognition by the COP1 Tumor Suppressor

Oncoproteins and tumor suppressors antagonistically converge on critical nodes governing neoplastic growth, invasion, and metastasis. We discovered that phosphorylation of the ETS1 and ETS2 transcriptional oncoproteins at specific serine or threonine residues creates binding sites for the COP1 tumor...

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Main Authors: Lu, Gang (Author), Zhang, Qing (Author), Huang, Ying (Author), Song, Jiaxi (Author), Lim, Elgene (Author), Liu, Wenbin (Author), Bronson, Roderick T (Author), Bowden, Michaela (Author), Brock, Jane (Author), Krop, Ian E. (Author), Dillon, Deborah A (Author), Gygi, Steven P (Author), Mills, Gordon B (Author), Richardson, Andrea L (Author), Signoretti, Sabina (Author), Kaelin, William G (Author), Tomaino, Ross (Author), Yaffe, Michael B (Contributor), Ehrenberger, Tobias (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-12-19T15:13:23Z.
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