A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

The "cancerized field" concept posits that cancer-prone cells in a given tissue share an oncogenic mutation, but only discreet clones within the field initiate tumors. Most benign nevi carry oncogenic BRAF[superscript V600E] mutations but rarely become melanoma. The zebrafish crestin gene...

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Main Authors: Kaufman, C. K. (Author), Mosimann, C. (Author), Yang, S. (Author), Thomas, A. J. (Author), Ablain, J. (Author), Tan, J. L. (Author), Fogley, R. D. (Author), van Rooijen, E. (Author), Hagedorn, E. J. (Author), Ciarlo, C. (Author), White, R. M. (Author), Matos, D. A. (Author), Puller, A.-C (Author), Santoriello, C. (Author), Liao, E. C. (Author), Zon, L. I. (Author), Fan, Zi Peng (Contributor), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2016-12-19T16:29:02Z.
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