Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

Since the discovery of NAD-dependent deacetylase activity of the silent information regulator-2 (SIR2) family ('sirtuins'), many exciting connections between protein deacetylation and energy metabolism have been revealed. The importance of sirtuins in the regulation of many fundamental bio...

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Bibliographic Details
Main Authors: Imai, Shin-ichiro (Author), Guarente, Leonard Pershing (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-01-12T19:04:28Z.
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