An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

In certain human cancers, the expression of critical oncogenes is driven from large regulatory elements, called super-enhancers, which recruit much of the cell's transcriptional apparatus and are defined by extensive acetylation of histone H3 lysine 27 (H3K27ac). In a subset of T-cell acute lym...

Full description

Bibliographic Details
Main Authors: Mansour, M. R. (Author), Abraham, B. J. (Author), Anders, L. (Author), Berezovskaya, A. (Author), Gutierrez, A. (Author), Durbin, A. D. (Author), Etchin, J. (Author), Lawton, L. (Author), Sallan, S. E. (Author), Silverman, L. B. (Author), Loh, M. L. (Author), Hunger, S. P. (Author), Sanda, T. (Author), Look, A. T. (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Young, Richard A (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-01-12T19:27:14Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items