A Drosophila model of Huntington disease-like 2 exhibits nuclear toxicity and distinct pathogenic mechanisms from Huntington disease
Huntington disease-like 2 (HDL2) and Huntington disease (HD) are adult-onset neurodegenerative diseases characterized by movement disorders, psychiatric disturbances and cognitive decline. Brain tissue from HD and HDL2 patients shows degeneration of the striatum and ubiquitinated inclusions immunore...
Main Authors: | , , |
---|---|
Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Oxford University Press,
2017-01-18T15:34:58Z.
|
Subjects: | |
Online Access: | Get fulltext |