The apo-structure of the leucine sensor Sestrin2 is still elusive
Sestrin2 is a GATOR2-interacting protein that directly binds leucine and is required for the inhibition of mTORC1 under leucine deprivation, indicating that it is a leucine sensor for the mTORC1 pathway. We recently reported the structure of Sestrin2 in complex with leucine [Protein Data Bank (PDB)...
| Main Authors: | , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
American Association for the Advancement of Science (AAAS),
2017-01-26T16:07:05Z.
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| Subjects: | |
| Online Access: | Get fulltext |