Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes

Highly Predictive Reprogramming of tRNA Modifications Is Linked to Selective Expression of Codon-Biased Genes

Cells respond to stress by controlling gene expression at several levels, with little known about the role of translation. Here, we demonstrate a coordinated translational stress response system involving stress-specific reprogramming of tRNA wobble modifications that leads to selective translation...

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Bibliographic Details
Main Authors: Begley, Thomas J. (Author), Li, Fugen (Author), Chan, Clement T. Y. (Contributor), Deng, Wenjun (Contributor), DeMott, Michael S (Contributor), Babu, I. Ramesh (Contributor), Dedon, Peter C (Contributor)
Other Authors: Massachusetts Institute of Technology. Center for Environmental Health Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: American Chemical Society, 2017-01-26T19:19:06Z.
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