Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

Transcriptome-wide Mapping Reveals Widespread Dynamic-Regulated Pseudouridylation of ncRNA and mRNA

Pseudouridine is the most abundant RNA modification, yet except for a few well-studied cases, little is known about the modified positions and their function(s). Here, we develop Ψ-seq for transcriptome-wide quantitative mapping of pseudouridine. We validate Ψ-seq with spike-ins and de novo identifi...

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Bibliographic Details
Main Authors: Schwartz, Schraga (Author), Bernstein, Douglas A (Author), Mumbach, Maxwell R (Author), Jovanovic, Marko (Author), Herbst, Rebecca H (Author), León-Ricardo, Brian X (Author), Guttman, Mitchell (Author), Satija, Rahul (Author), Fink, Gerald (Author), Engreitz, Jesse Michael (Contributor), Lander, Eric Steven (Contributor), Regev, Aviv (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-02-02T15:28:58Z.
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