Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Thousands of human diseases could be treated by selectively controlling the expression of specific proteins in vivo. A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs) capable of delivering human mRNA with unprecedented levels of in vivo efficacy is demonstrated. This s...

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Main Authors: DeRosa, Frank (Author), Langer, Robert (Author), Kauffman, Kevin John (Contributor), McClellan, Rebecca L (Contributor), Appel, Eric (Contributor), Dorkin, Joseph Robert (Contributor), Tibbitt, Mark W (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor), Fenton, Owen Shea (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Fenton, Owen S. (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2017-02-10T15:50:07Z.
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