Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Glucose-dependent anaplerosis in cancer cells is required for cellular redox balance in the absence of glutamine

Cancer cells have altered metabolism compared to normal cells, including dependence on glutamine (GLN) for survival, known as GLN addiction. However, some cancer cell lines do not require GLN for survival and the basis for this discrepancy is not well understood. GLN is a precursor for antioxidants...

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Bibliographic Details
Main Authors: Cetinbas, Naniye Mallı (Author), Sudderth, Jessica (Author), Harris, Robert C. (Author), Negri, Gian L. (Author), DeBerardinis, Ralph J. (Author), Sorensen, Poul H. (Author), Yilmaz, Omer (Contributor), Cebeci Aydin, Aysun (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-02-14T18:50:53Z.
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