RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

Myocardial infarction (MI) leads to a systemic surge of vascular inflammation in mice and humans, resulting in secondary ischemic complications and high mortality. We show that, in ApoE−/− mice with coronary ligation, increased sympathetic tone up-regulates not only hematopoietic leukocyte productio...

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Main Authors: Sager, H. B. (Author), Dutta, P. (Author), Hulsmans, M. (Author), Courties, G. (Author), Sun, Y. (Author), Heidt, T. (Author), Vinegoni, C. (Author), Borodovsky, A. (Author), Fitzgerald, K. (Author), Wojtkiewicz, G. R. (Author), Iwamoto, Y. (Author), Tricot, B. (Author), Libby, P. (Author), Weissleder, R. (Author), Swirski, F. K. (Author), Nahrendorf, M. (Author), Xing, Yiping (Contributor), Shaw, Taylor E. (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor), Khan, Omar Fizal (Contributor), Kauffman, Kevin John (Contributor), Dahlman, James E. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dahlman, James (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-02-14T20:56:02Z.
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