Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Safe and effective delivery is required for siRNA and mRNA-based therapeutics to reach their potential. Here, we report on the development of poly(glycoamidoamine) brush nanoparticles as delivery vehicles for siRNA and mRNA. These polymers were capable of significant delivery of siRNA against FVII a...

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Main Authors: Abutbul-Ionita, Inbal (Author), Danino, Dganit (Author), DeRosa, Frank (Author), Heartlein, Michael (Author), Dong, Yizhou (Contributor), Dorkin, Joseph Robert (Contributor), Wang, Weiheng (Contributor), Webber, Matthew (Contributor), Tang, Benjamin C. (Contributor), Yang, Jung H (Contributor), Langer, Robert S (Contributor), Anderson, Daniel Griffith (Contributor), Chang, Philip H. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Chang, Philip (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2017-02-23T14:38:43Z.
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