Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Thymic CD4 T cell selection requires attenuation of March8-mediated MHCII turnover in cortical epithelial cells through CD83

Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs thymic CD4 T cell selection. CD83 can exert cell-intrinsic and -extrinsic functions through discrete protein domains, but it remains unclear how CD83's capacity to operate through these alternative functional modules rela...

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Bibliographic Details
Main Authors: von Rohrscheidt, Julia (Author), Petrozziello, Elisabetta (Author), Nedjic, Jelena (Author), Federle, Christine (Author), Krzyzak, Lena (Author), Ishido, Satoshi (Author), Steinkasserer, Alexander (Author), Klein, Ludger (Author), Ploegh, Hidde (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2017-02-23T20:17:54Z.
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