Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Oncogenic KRAS Regulates Tumor Cell Signaling via Stromal Reciprocation

Oncogenic mutations regulate signaling within both tumor cells and adjacent stromal cells. Here, we show that oncogenic KRAS (KRAS[superscript G12D]) also regulates tumor cell signaling via stromal cells. By combining cell-specific proteome labeling with multivariate phosphoproteomics, we analyzed h...

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Bibliographic Details
Main Authors: Ling, Stephanie (Author), Dimitriadi, Maria (Author), McMahon, Kelly M (Author), Worboys, Jonathan D (Author), Leong, Hui Sun (Author), Norrie, Ida C (Author), Miller, Crispin J (Author), Poulogiannis, George (Author), Jørgensen, Claus (Author), Tape, Christopher (Contributor), Lauffenburger, Douglas A (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-03-22T20:08:18Z.
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