Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy

The development of a tuberculosis (TB) vaccine that induces sterilizing immunity to Mycobacterium tuberculosis infection has been elusive. Absence of sterilizing immunity induced by TB vaccines may be due to delayed activation of mucosal dendritic cells (DCs), and subsequent delay in antigen present...

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Main Authors: Griffiths, Kristin L. (Author), Ahmed, Mushtaq (Author), Das, Shibali (Author), Gopal, Radha (Author), Horne, William (Author), Connell, Terry D. (Author), Kolls, Jay K. (Author), Artyomov, Maxim N. (Author), Rangel-Moreno, Javier (Author), Khader, Shabaana A. (Author), Moynihan, Kelly Dare (Contributor), Irvine, Darrell J (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor)
Format: Article
Language:English
Published: Springer Nature, 2017-03-27T15:20:19Z.
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