Engineering and optimising deaminase fusions for genome editing

Engineering and optimising deaminase fusions for genome editing

Precise editing is essential for biomedical research and gene therapy. Yet, homology-directed genome modification is limited by the requirements for genomic lesions, homology donors and the endogenous DNA repair machinery. Here we engineered programmable cytidine deaminases and test if we could intr...

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Main Authors: Yang, Luhan (Author), Briggs, Adrian W. (Author), Chew, Wei Leong (Author), Mali, Prashant (Author), Guell, Marc (Author), Aach, John (Author), Kan, Yinan (Author), Lesha, Emal (Author), Soundararajan, Venkataramanan (Author), Goodman, Daniel Bryan (Contributor), Cox, David (Contributor), Church, George M (Contributor), Zhang, Feng (Contributor)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Program in Media Arts and Sciences (Massachusetts Institute of Technology) (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-03-28T17:44:33Z.
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