Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche

The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1⁺ stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutatio...

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Main Authors: Hayakawa, Yoku (Author), Ariyama, Hiroshi (Author), Stancikova, Jitka (Author), Sakitani, Kosuke (Author), Asfaha, Samuel (Author), Renz, Bernhard W (Author), Dubeykovskaya, Zinaida A (Author), Shibata, Wataru (Author), Wang, Hongshan (Author), Westphalen, Christoph B (Author), Chen, Xiaowei (Author), Takemoto, Yoshihiro (Author), Kim, Woosook (Author), Khurana, Shradha S (Author), Tailor, Yagnesh (Author), Nagar, Karan (Author), Tomita, Hiroyuki (Author), Hara, Akira (Author), Sepulveda, Antonia R (Author), Setlik, Wanda (Author), Gershon, Michael D (Author), Saha, Subhrajit (Author), Ding, Lei (Author), Friedman, Richard A (Author), Konieczny, Stephen F (Author), Worthley, Daniel L (Author), Korinek, Vladimir (Author), Wang, Timothy C. (Author), Shen, Zeli (Contributor), Fox, James G (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-03-29T16:17:09Z.
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