Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Dose-Dependent Regulation of Alternative Splicing by MBNL Proteins Reveals Biomarkers for Myotonic Dystrophy

Alternative splicing is a regulated process that results in expression of specific mRNA and protein isoforms. Alternative splicing factors determine the relative abundance of each isoform. Here we focus on MBNL1, a splicing factor misregulated in the disease myotonic dystrophy. By altering the conce...

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Bibliographic Details
Main Authors: Wagner, Stacey D. (Author), Struck, Adam J. (Author), Gupta, Riti (Author), Farnsworth, Dylan R. (Author), Mahady, Amy E. (Author), Eichinger, Katy (Author), Thornton, Charles A. (Author), Berglund, J. Andrew (Author), Wang, Eric T (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-04-03T15:11:36Z.
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