A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

Serine is a both a proteinogenic amino acid and the source of one-carbon units essential for de novo purine and deoxythymidine synthesis. In the canonical glucose-derived serine synthesis pathway, Homo sapiens phosphoglycerate dehydrogenase (PHGDH) catalyzes the first, ratelimiting step. Genetic los...

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Main Authors: Chan, Sze Ham (Contributor), Lewis, Caroline (Contributor), Swier, Lotteke J. Y. M. (Contributor), Chen, Walter W. (Contributor), Sullivan, Lucas Bryan (Contributor), Fiske, Brian Prescott (Contributor), Cho, Sung Won (Contributor), Abu-Remaileh, Monther (Contributor), Liu, Chieh Ming Jamin (Contributor), Zhou, Minerva H. (Contributor), Koh, Min Jung (Contributor), Chung, Haeyoon (Contributor), Davidson, Shawn M (Contributor), Luengo, Alba (Contributor), Vander Heiden, Matthew G. (Contributor), Sabatini, David (Contributor), Pacold, Michael Edward (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Pacold, Michael E (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-04-05T18:49:45Z.
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