Calcium Dynamics of Ex Vivo Long-Term Cultured CD8+ T Cells Are Regulated by Changes in Redox Metabolism

T cells reach a state of replicative senescence characterized by a decreased ability to proliferate and respond to foreign antigens. Calcium release associated with TCR engagement is widely used as a surrogate measure of T cell response. Using an ex vivo culture model that partially replicates featu...

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Bibliographic Details
Main Authors: Rivet, Catherine A. (Author), Kniss-James, Ariel S. (Author), Gran, Margaret A. (Author), Potnis, Anish (Author), Hill, Abby (Contributor), Lu, Hang (Author), Kemp, Melissa L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-04-07T14:53:21Z.
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