Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs

Therapeutic nucleic acids hold great promise for the treatment of disease but require vectors for safe and effective delivery. Synthetic nanoparticle vectors composed of poly(β-amino esters) (PBAEs) and nucleic acids have previously demonstrated potential utility for local delivery applications. To...

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Bibliographic Details
Main Authors: Heartlein, Michael W. (Author), DeRosa, Frank (Author), Kaczmarek, James Cliff (Contributor), Kauffman, Kevin John (Contributor), Webber, Matthew (Contributor), Anderson, Daniel Griffith (Contributor), Patel, Asha (Author), Fenton, Owen Shea (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Patel, Asha K (Contributor), Fenton, Owen S. (Contributor)
Format: Article
Language:English
Published: Wiley Blackwell, 2017-04-07T15:18:02Z.
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