MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment

Rather than targeting tumour cells directly, elements of the tumour microenvironment can be modulated to sensitize tumours to the effects of therapy. Here we report a unique mechanism by which ectopic microRNA-103 can manipulate tumour-associated endothelial cells to enhance tumour cell death. Using...

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Main Authors: Wilson, RaeAnna (Author), Espinosa-Diez, Cristina (Author), Kanner, Nathan (Author), Chatterjee, Namita (Author), Ruhl, Rebecca (Author), Hipfinger, Christina (Author), Advani, Sunil J. (Author), Li, Jie (Author), Franovic, Aleksandra (Author), Weis, Sara M. (Author), Coussens, Lisa M. (Author), Chen, Clark C. (Author), Cheresh, David A. (Author), Anand, Sudarshan (Author), Khan, Omar Fizal (Contributor), Anderson, Daniel Griffith (Contributor), Kumar, Sushil, Ph. D. Massachusetts Institute of Technology (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-04-07T17:54:53Z.
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