Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling

Interleukins 7 and 15 Maintain Human T Cell Proliferative Capacity through STAT5 Signaling

T lymphocytes require signals from self-peptides and cytokines, most notably interleukins 7 and 15 (IL-7, IL-15), for survival. While mouse T cells die rapidly if IL-7 or IL-15 is withdrawn, human T cells can survive prolonged withdrawal of IL-7 and IL-15. Here we show that IL-7 and IL-15 are requir...

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Bibliographic Details
Main Authors: Drake, Adam (Contributor), Kaur, Mandeep (Contributor), Iliopoulou, Bettina P. (Author), Phennicie, Ryan (Author), Hanson, Amanda (Contributor), Chen, Jianzhu (Contributor), Phennicie, Ryan T. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Iliopoulou, Panagiota (Contributor)
Format: Article
Language:English
Published: Public Library of Science, 2017-04-07T18:14:32Z.
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