Sestrin2 is a leucine sensor for the mTORC1 pathway

Sestrin2 is a leucine sensor for the mTORC1 pathway

Leucine is a proteogenic amino acid that also regulates many aspects of mammalian physiology, in large part by activating the mTOR complex 1 (mTORC1) protein kinase, a master growth controller. Amino acids signal to mTORC1 through the Rag guanosine triphosphatases (GTPases). Several factors regulate...

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Main Authors: Shen, K. (Author), Cantor, J. R. (Author), Wolfson, Rachel Laura (Contributor), Chantranupong, Lynne (Contributor), Saxton, Robert Andrew (Contributor), Scaria, Sonia M. (Contributor), Sabatini, David (Contributor)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-04-07T18:36:39Z.
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