Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development, Implications for the Treatment of Vein Graft Failure

Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development, Implications for the Treatment of Vein Graft Failure

Objective-Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease. Approach and Results-We used 2 biotherapeutics for Delta-like...

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Main Authors: Koga, Jun-ichiro (Author), Nakano, Toshiaki (Author), Figueiredo, Jose-Luiz (Author), Zhang, Hengmin (Author), Decano, Julius (Author), Khan, Omar F. (Author), Niida, Tomiharu (Author), Iwata, Hiroshi (Author), Aster, Jon C. (Author), Yagita, Hideo (Author), Ozaki, C. Keith (Author), Aikawa, Masanori (Author), Anderson, Daniel Griffith (Contributor), Dahlman, James E. (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Dahlman, James (Contributor)
Format: Article
Language:English
Published: Wolters Kluwer Health, Inc., 2017-04-10T13:34:41Z.
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