RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

RagA, but Not RagB, Is Essential for Embryonic Development and Adult Mice

The mechanistic target of rapamycin complex 1 (mTORC1) integrates cues from growth factors and nutrients to control metabolism. In contrast to the growth factor input, genetic disruption of nutrient-dependent activation of mTORC1 in mammals remains unexplored. We engineered mice lacking RagA and Rag...

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Bibliographic Details
Main Authors: Kirak, Oktay (Author), Efeyan, Alejo (Contributor), Schweitzer, Lawrence David (Contributor), Bilate, Angelina M (Contributor), Chang, Steven H. (Contributor), Lamming, Dudley (Contributor), Sabatini, David (Contributor)
Other Authors: Broad Institute of MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-12T19:34:05Z.
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