Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

Eukaryotic cells coordinate growth with the availability of nutrients through the mechanistic target of rapamycin complex 1 (mTORC1), a master growth regulator. Leucine is of particular importance and activates mTORC1 via the Rag guanosine triphosphatases and their regulators GATOR1 and GATOR2. Sest...

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Main Authors: Saxton, Robert Andrew (Contributor), Wolfson, Rachel Laura (Contributor), Chantranupong, Lynne (Contributor), Wang, Tim (Contributor), Schwartz, Thomas (Contributor), Sabatini, David (Contributor), Knockenhauer, Kevin Edward (Contributor), Pacold, Michael Edward (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Pacold, Michael E (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2017-04-13T14:36:24Z.
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