Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

Lineage-specific RUNX3 hypomethylation marks the preneoplastic immune component of gastric cancer

Runt domain transcription factor 3 (RUNX3) is widely regarded as a tumour-suppressor gene inactivated by DNA hypermethylation of its canonical CpG (cytidine-phosphate-guanidine) island (CGI) promoter in gastric cancer (GC). Absence of RUNX3 expression from normal gastric epithelial cells (GECs), the...

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Main Authors: Kurklu, B (Author), Whitehead, R H (Author), Ong, E K (Author), Minamoto, T (Author), Mann, J R (Author), Judd, L M (Author), Giraud, A S (Author), Menheniott, T R (Author), Fox, James G (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor)
Format: Article
Language:English
Published: Nature Publishing Group, 2017-04-14T20:42:10Z.
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