Targeting MTHFD2 in acute myeloid leukemia

Targeting MTHFD2 in acute myeloid leukemia

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Drugs targeting metabolism have formed the backbone of therapy for some cancers. We sought to identify new such targets in acute myeloid leukemia (AML). The one-carbon folate pathway, specifically methylenetetrahydrofolate dehydrogenase-cyclohydrolase 2 (MTHFD2), emerged as a top candidate in our an...

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Main Authors: Pikman, Yana (Author), Puissant, Alexandre (Contributor), Alexe, Gabriela (Author), Furman, Andrew (Author), Chen, Liying M. (Author), Frumm, Stacey M. (Author), Ross, Linda (Author), Fenouille, Nina (Author), Bassil, Christopher F. (Author), Lewis, Caroline (Contributor), Ramos, Azucena (Contributor), Gould, Joshua (Author), Stone, Richard M. (Author), DeAngelo, Daniel J. (Author), Galinsky, Ilene (Author), Clish, Clary B. (Author), Kung, Andrew L. (Author), Hemann, Michael (Contributor), Vander Heiden, Matthew G. (Contributor), Banerji, Versha (Author), Stegmaier, Kimberly (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Rockefeller University Press, 2022-02-09T19:25:34Z.
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