RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Interleukin-17 (IL-17)-producing helper T cells (Th17 cells) play an important role in autoimmune diseases. However, not all Th17 cells induce tissue inflammation or autoimmunity. Th17 cells require IL-23 receptor (IL-23R) signaling to become pathogenic. The transcriptional mechanisms controlling th...

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Bibliographic Details
Main Authors: Meyer zu Horste, Gerd (Author), Wu, Chuan (Author), Wang, Chao (Author), Cong, Le (Author), Pawlak, Mathias (Author), Lee, Youjin (Author), Elyaman, Wassim (Author), Xiao, Sheng (Author), Regev, Aviv (Contributor), Kuchroo, Vijay K (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-18T20:30:56Z.
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