Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Systematic Identification of Factors for Provirus Silencing in Embryonic Stem Cells

Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), s...

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Main Authors: Yang, Bin Xia (Author), EL Farran, Chadi A (Author), Guo, Hong Chao (Author), Yu, Tao (Author), Fang, Hai Tong (Author), Wang, Hao Fei (Author), Schlesinger, Sharon (Author), Seah, Yu Fen Samantha (Author), Goh, Germaine Yen Lin (Author), Neo, Suat Peng (Author), Li, Yinghui (Author), Lorincz, Matthew C (Author), Tergaonkar, Vinay (Author), Lim, Tit-Meng (Author), Chen, Lingyi (Author), Gunaratne, Jayantha (Author), Goff, Stephen P (Author), Daley, George Q (Author), Li, Hu (Author), Bard, Frederic A (Author), Loh, Yuin-Han (Author), Collins, James J. (Contributor)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier, 2017-04-21T17:23:53Z.
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